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Coadministration of zuranolone with other CNS depressants might maximize impairment of psychomotor general performance or CNS depressant consequences. If unavoidable, look at dose reduction. .
pentobarbital will lower the level or effect of ramelteon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Mysterious.
Keep track of Intently (one)pentobarbital will minimize the extent or effect of mestranol by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will decrease the level or result of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Pitolisant publicity is reduced by 50% if coadministered with powerful CYP3A4 inducers.
pentobarbital decreases effects of sufentanil SL by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of CYP3A4 inducers may well minimize sufentanil amounts and efficacy, quite possibly precipitating withdrawal syndrome in clients who have developed physical dependence to sufentanil. Discontinuation of concomitantly applied CYP3A4 inducers may well increase sufentanil plasma concentration.
The use of barbiturates as sedatives in the postoperative surgical period and as adjuncts to most check here cancers chemotherapy is effectively established
pentobarbital will decrease the level or influence of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will reduce the extent or effect of fosaprepitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will reduce the level or effect of dutasteride by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.
pentobarbital will decrease the extent or influence of diazepam buccal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Powerful or reasonable CYP3A4 inducers may maximize charge of diazepam elimination; therefore, efficacy of diazepam may be diminished.
Reserve concomitant prescribing of those medicines in patients for whom other treatment choices are insufficient. Limit dosages and durations towards the bare minimum needed. Observe closely for signs of respiratory despair and sedation.
pentobarbital will minimize the extent or influence of almotriptan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.